Modeling Depolarization Induced Suppression of Inhibition in Pyramidal Neurons
نویسندگان
چکیده
Depolarization-Induced Suppression of Inhibition (DSI) is effectively a mechanism for feedback-inhibition of inhibition. Wilson and Nicoll [4] showed that its effect is mediated through a retrograde endocannabinoid signal. Here, we produced a simple model for DSI which matched the effects and kinetics of DSI found in empirical data. We then explored a possible function for DSI through examining its effects on shaping orientation tuning curves. DSI demonstrated a dramatic effect on the shape of the tuning curve, indicating that it may play a similar role in-vivo.
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